Celtic's hopes of advancing in the Europa League were dashed by a late retaliation from Bayer Leverkusen denied them a famous victory in Germany.
The spirited team of Ange Postecoglou knew she would probably need a win to keep her dream of the Last 32 alive and she was on track to the finals after a penaltyfrom Josip Juranovic and a strike from Jota canceled Robert Andrich's first goal for the hosts.
However, Leverkusen fought back twice in the last eight minutes to win 3-2 and dominate the group.
The result means Celtic will join the League Conference after Christmas, with Real Betis underway in the Europa League as a finalist.
Celtic made a change to the squad that beat St Johnstone in the Premier Sports Cup semi-finals on Saturday, with James Forrest making his first start in more than three months replacing Liel Abada.
The Germans signaled their intention in the 10th minute when Andrich took off from a corner by Florian Wirtz.
Celtic looked reasonably comfortable at first, although Cameron Carter-Vickers had to make a vital clearance from inside his own six-yard penalty area when Jeremie Frimpong rushed into the surface and pierced a dangerous low ball in front of goal in the 12th minute.
The visitors ignored Leverkusen 's warning on the turn earlier, and they fell behind in the 16th minute when Andrich edged out Stephen Welsh to lead another Wirtz delivery.
Celtic had a rare foray into forward in the In the 35th minute, David Turnbull passed a ball deep behind for Kyogo Furuhashi, but the offside flag was raised when the Japanese striker burst into the box and landed an angled shot. weak just behind the far post.
Held for long periods of match, visitors found themselvess tied in the 39th minute with a penalty awarded following a VAR review after Leverkusen goalkeeper Lukas Hradecky collided with Kyogo while trying to defend a cross into Jota's box.
Hradecky was warned and Juranovic produced a nonchalant finish as he kicked off below the crossbar.
Juranovic was fortunate enough to get away with a slip in the 44th minute when he gave an inexpensive kick just outside his zone, allowing Moussa Diaby to Fire a powerful angled half volley off the post before Wirtz sends the rebound crashing into the opposite post.
Celtic had another Major Clearance eight minutes after the break when Joe Hart made a brilliant double save to fend off Diaby and then Amine Adli.
Remarkably, Celtic took the advantage in the 56th . minute when Jota piercedin a low angle clinical shot just inside the box after being sent off by Kyogo following brilliant play from Forrest and Nir Bitton.
Hart made a few saves to deny Adli as the Scots began to believe they could come close to their first victory in Germany. But Andrich ended their hopes in the 82nd minute when he punched a low shot in Hart's legs from 12 yards after being put in place by substitute Nadiem Amiri.
The hosts then claimed victory in the 87th minute when Diab came home on the fly after being selected by a pass from Wirtz.